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Related Experiment Videos

Genetics of aging

C E Finch1, R E Tanzi

  • 1Neurogerontology Division, Andrus Gerontology Center, and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA.

Science (New York, N.Y.)
|October 23, 1997
PubMed
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Genetics play a complex role in lifespan. While heritability is minor, specific gene variants impact aging and lifespan, interacting with lifestyle and environmental factors.

Area of Science:

  • Genetics and Aging Research
  • Molecular Biology
  • Gerontology

Background:

  • The heritability of human lifespan is relatively low.
  • Certain genetic variants significantly influence the aging process (senescence) in various organisms.
  • These genetic factors can have both beneficial and detrimental effects on age-related diseases and longevity.

Purpose of the Study:

  • To explore the complex and often paradoxical role of genetics in determining lifespan.
  • To investigate how genetic variants interact with environmental factors to influence aging.
  • To understand the impact of genetic modifications on senescence and age-related disorders.

Main Methods:

  • Review of existing literature on genetics and lifespan.
  • Analysis of studies on genetic variants affecting senescence in mammals and invertebrates.

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  • Examination of the interplay between genetic factors, metabolic pathways, and environmental influences on aging.

    • Main Results:

    • Genetic variants can significantly alter metabolic pathways, mediating interactions with environmental factors.
    • The impact of genetic risk factors on survival and health in advanced age is often minor and shows variable penetrance.
    • Environmental and lifestyle factors play a profound role in modifying aging outcomes.

    Conclusions:

    • Genetics contribute to lifespan determination, but their influence is complex and interacts with other factors.
    • Environmental and lifestyle choices significantly modulate the effects of genetic predispositions on aging and longevity.
    • Further research is needed to fully elucidate the genetic and environmental interactions governing lifespan.