[Monoreceptor sera to the antigenic determinants of influenza virus A hemagglutinin]

The method of specific adsorption was used to produce monoreceptor sera to individual antigenic determinants of hemagglutinin of influenza A virus, Hong Kong variant. The sera were completely free of inhibitors, contained no antibody to neuraminidase or host cell antigens. The monoreceptor sera were used in HI tests and immunoelectrophoresis for the qualitative and quantitative analysis of the antigenic variants isolated in 1968--1977. It was shown that alongside with the appearance of qualitatively new antigenic determinants changes in the content of some or other antigens in influenza virus hemagglutinins occurred.