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Chorea-acanthocytosis with polyclonal antibodies to ganglioside GM1
M Hirayama1, T Hamano, M Shiratori
1Second Department of Internal Medicine, Fukui Medical School, Japan.
Journal of the Neurological Sciences
|October 23, 1997
Abstract:
A patient with chorea-acanthocytosis presenting with axonal neuropathy showed an elevation in IgM polyclonal antibodies to the GM1 ganglioside, which were estimated by enzyme-linked immunosorbent assay and complement-mediated liposome immune lysis assay (LILA). This is the first demonstration of such antibodies in chorea-acanthocytosis. Anti-GM1 antibodies might have directly caused the axonal neuropathy by binding to GM1 or cross-reactive antigens in the nerves.