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Related Experiment Videos

Drug discrimination under a concurrent fixed-interval fixed-interval schedule

D E McMillan1, M Li, W C Hardwick

  • 1Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205, USA. mcmillandonalde@exchange.uams.edu

Journal of the Experimental Analysis of Behavior
|October 23, 1997
PubMed
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Pigeons learned to associate pentobarbital with a shorter food reward schedule. This drug discrimination study shows how different substances alter choice behavior under concurrent schedules.

Area of Science:

  • Behavioral pharmacology
  • Animal models of drug effects
  • Operant conditioning

Background:

  • Understanding drug effects on behavior is crucial for pharmacology.
  • Concurrent schedules of reinforcement are used to study choice behavior.

Purpose of the Study:

  • To investigate how pentobarbital and other drugs affect choice behavior in pigeons.
  • To examine drug discrimination under concurrent fixed-interval schedules.

Main Methods:

  • Pigeons were trained to discriminate pentobarbital from saline using concurrent fixed-interval schedules.
  • Drug substitution tests were conducted using pentobarbital, ethanol, and chlordiazepoxide.
  • Response proportions on different keys were analyzed.

Main Results:

Related Experiment Videos

  • Pigeons consistently chose the key associated with a shorter interval (FI 60s) after pentobarbital administration.
  • Pentobarbital, ethanol, and chlordiazepoxide increased responding on the FI 60s key.
  • Phencyclidine and methamphetamine showed different patterns of responding compared to pentobarbital.

Conclusions:

  • The study demonstrates a reliable drug discrimination of pentobarbital in pigeons.
  • Concurrent schedules effectively reveal drug-induced alterations in choice behavior.
  • Different drugs produce distinct behavioral effects under these conditions.