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An open study of lamotrigine in refractory bipolar depression
1Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Psychiatry Research
|October 23, 1997
Abstract:
Bipolar depressed patients (n = 22) who were refractory to treatment with a combination of divalproex sodium (DVP) and another mood stabilizer or DVP and an antidepressant for 6 weeks were treated in an open naturalistic study with an addition of lamotrigine to DVP. Sixteen out of 22 (72%) responded by the end of week 4 and none developed rash or switched to mania. The results of this preliminary study suggest that lamotrigine may be useful in bipolar depression.