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Malignant proliferating trichilemmal tumor showing distant metastases
1Department of Dermatology, Seoul National University College of Medicine, Korea.
The American Journal of Dermatopathology
|October 23, 1997
Summary
Malignant proliferating trichilemmal tumors can metastasize distantly. This case highlights tumor recurrence and spread to lymph nodes and chest, with increasing atypia and Ki-67 positivity.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Proliferating trichilemmal tumors (PTT) are rare adnexal neoplasms.
- Malignant transformation of PTT is uncommon, but can occur.
Observation:
- A patient presented with a decade-long history of a recurrent occipital mass.
- The tumor subsequently metastasized to cervical lymph nodes, periparotid area, and chest.
Findings:
- Histological examination revealed malignant proliferating trichilemmal tumor with increasing nuclear atypia over time.
- Serial specimens demonstrated escalating Ki-67 proliferation index correlating with tumor advancement.
Implications:
- This case underscores the potential for aggressive behavior and distant metastasis in malignant PTT.
- Highlights the importance of vigilant monitoring and potentially aggressive management for PTT with concerning features.