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The double-stranded RNA-dependent protein kinase PKR: structure and function

M J Clemens1, A Elia

  • 1Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, London, U.K.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
|October 23, 1997
PubMed
Summary
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The interferon-inducible protein kinase PKR regulates translation and cell growth. Its roles in antiviral defense, stress response, and potential tumor suppression highlight its importance in controlling cell proliferation and transformation.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • The double-stranded RNA-activated protein kinase PKR is interferon-inducible.
  • PKR plays critical roles in regulating cellular processes.
  • Extensive research has elucidated PKR's structure, function, and regulation.

Purpose of the Study:

  • To review the structure and function of PKR.
  • To summarize the accumulated evidence on PKR's expression, interactions, activation, and inhibition.
  • To highlight PKR's diverse roles in cellular regulation and its potential implications in disease.

Main Methods:

  • Literature review of existing studies on PKR.
  • Analysis of expression studies using wild-type and dominant-negative PKR mutants.

Related Experiment Videos

  • Examination of PKR's phosphorylation targets and regulatory interactions.

    • Main Results:

    • PKR regulates translation, transcription, and signal transduction by phosphorylating key substrates like eIF2 and I-kappaB.
    • PKR is involved in the antiviral effects of interferons (IFNs).
    • PKR mediates cellular responses to physiological stresses and regulates cell growth.

    Conclusions:

    • PKR is a crucial regulator of cellular processes, including translation and cell growth.
    • PKR's involvement in antiviral responses, stress signaling, and cell cycle control is well-established.
    • PKR's potential functions as a tumor suppressor and inducer of apoptosis underscore its significance in controlling cell proliferation and transformation.