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Arterial calcification in face of osteoporosis in ageing: can we blame oxidized lipids?

F Parhami1, L L Demer

  • 1UCLA Division of Cardiology, School of Medicine 90095, USA.

Current Opinion in Lipidology
|October 23, 1997
PubMed

Insights

Vascular calcification, common in older adults, lacks prevention strategies due to unknown mechanisms. This review explores vessel mineralization, comparing it to bone, and highlights lipid oxidation

Area of Science:

  • Cardiovascular Biology
  • Vascular Biology
  • Mineralization Biology

Background:

  • Vascular calcification affects most individuals over 70, leading to cardiovascular dysfunction.
  • Current prevention and management strategies are lacking due to unknown pathogenesis.
  • Similarities between vascular and bone mineralization are increasingly recognized.

Purpose of the Study:

  • To summarize current understanding of atherosclerotic calcification mechanisms.
  • To explore potential explanations for vascular calcification coexisting with osteoporosis.
  • To emphasize the role of lipid oxidation products in vascular calcification.

Main Methods:

  • Literature review of mechanisms in atherosclerotic calcification.
  • Analysis of observations regarding vascular calcification and osteoporosis.
  • Focus on the role of lipid oxidation products.

Main Results:

  • Atherosclerotic calcification mechanisms are complex and not fully elucidated.
  • The paradox of vascular calcification alongside osteoporosis suggests underlying shared or contrasting pathways.
  • Lipid oxidation products emerge as a significant factor potentially influencing vascular calcification.

Conclusions:

  • Understanding the pathogenesis of vascular calcification is crucial for developing therapeutic strategies.
  • Further research into the interplay between lipid oxidation, bone metabolism, and vascular health is warranted.
  • Investigating the similarities and differences between vascular and bone mineralization may reveal novel therapeutic targets.

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