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Modulation of immune cell function by the autonomic nervous system

E M Friedman1, M R Irwin

  • 1Department of Psychiatry, University of California, San Diego, USA.

Pharmacology & Therapeutics
|January 1, 1997
PubMed
Summary

The autonomic nervous system, particularly the sympathetic nervous system, influences immune function. Neurohormones from this system interact with immune cells, affecting their function and potentially contributing to immune disorders.

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Area of Science:

  • Neuroimmunology
  • Autonomic Nervous System Research

Background:

  • The autonomic nervous system (ANS) plays a crucial role in maintaining homeostasis.
  • Emerging evidence suggests a significant interplay between the ANS and the immune system.

Purpose of the Study:

  • To review key findings on the autonomic nervous system's role in immune regulation.
  • To highlight the sympathetic nervous system's specific contributions to immune function.

Main Methods:

  • Literature review of studies investigating the neuro-immune axis.
  • Analysis of research on sympathetic innervation of lymphoid organs.
  • Examination of leukocyte receptor expression for neurohormones.

Main Results:

  • The sympathetic nervous system directly innervates major lymphoid organs.

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  • Sympathetic neurohormones are physiologically released at these sites.
  • Leukocytes express receptors for catecholamines and neuropeptide Y, mediating functional changes.

    • Conclusions:

    • Sympathetic nervous system activity directly modulates immune cell function.
    • Dysregulation of sympathetic pathways may contribute to immune abnormalities in chronic stress, depression, and aging.