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Related Experiment Videos

Systolic function in hypertensive men with concentric remodeling

D B Sadler1, G P Aurigemma, D W Williams

  • 1Division of Cardiology of the University of Massachusetts Medical Center, Worcester 01655, USA.

Hypertension (Dallas, Tex. : 1979)
|October 23, 1997
PubMed
Summary
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Hypertensive men with concentric remodeling show reduced systolic function, including lower stroke volume and impaired myocardial function, indicating potential health risks despite normal chamber function. This highlights the need for careful assessment in these patients.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Hypertensive patients with concentric remodeling may experience adverse outcomes.
  • Systolic function abnormalities are known in concentric left ventricular (LV) hypertrophy but are unclear in concentric remodeling.

Purpose of the Study:

  • To evaluate left ventricular (LV) pump, chamber, and myocardial function in hypertensive men with concentric remodeling.
  • To compare these functions against hypertensive men with normal LV geometry.

Main Methods:

  • Clinical and echocardiographic data from 118 hypertensive men with concentric remodeling and 104 controls were analyzed.
  • LV chamber function assessed via endocardial fractional shortening to stress.
  • Myocardial function assessed via midwall fractional shortening to stress; pump performance by stroke volume.

Related Experiment Videos

Main Results:

  • Concentric remodeling patients had lower stroke volume (84 vs. 111 mL, P < .001).
  • Midwall shortening was reduced (20% vs. 22%, P < .001) despite lower stress (81 vs. 117 g/cm2, P < .001).
  • 28% and 42% of remodeling patients had impaired endocardial and midwall function, respectively.

Conclusions:

  • Hypertensive men with concentric remodeling exhibit lower chamber, myocardial, and pump performance than those with normal geometry.
  • These findings suggest potential systolic function abnormalities in men with concentric remodeling.