Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

A simple method to calculate P50 from a single blood sample

¹Department of Anaesthesia, Toronto Hospital, Ontario, Canada.

International Journal of Clinical Monitoring and Computing

|January 1, 1997

Summary

This study presents a straightforward method to determine P50, a key indicator of oxygen transport, using a single blood sample. Sensitivity analysis confirms the method

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Use of GlideScope® in adults: an overview.

Minerva anestesiologica·2014

Same author

Use of REP-PCR and 16S rRNA gene sequencing for comparison of Mannheimia haemolytica isolates obtained from fatal cases of bovine respiratory disease in the USA and Australia.

Australian veterinary journal·2014

Same author

GlideScope® vs flexible fibreoptic scope for elective intubation in obese patients.

Anaesthesia·2011

Same author

The ethics of anaesthesia learning curves (comment).

Anaesthesia and intensive care·2010

Same author

Successful emergent reintubation using the Aintree intubation catheter and a laryngeal mask airway.

Minerva anestesiologica·2010

Same author

Imaging of hepatic infections.

Clinical radiology·2006

Area of Science:

Physiology
Biophysics

Background:

The P50 value is crucial for assessing oxygen-hemoglobin binding affinity.
Accurate determination of P50 is essential for clinical diagnostics and physiological research.

Purpose of the Study:

To introduce a simplified method for calculating P50 from a single blood sample.
To evaluate the impact of measurement errors on the P50 calculation.

Main Methods:

Utilized Hill's equation as the foundation for the P50 calculation.
Employed sensitivity analysis to assess the effects of oxygen tension and saturation measurement errors.
Validated the method using published data from Severinghaus.

Main Results:

A simple and effective method for P50 determination from a single blood sample was developed.
Sensitivity analysis quantified the influence of potential measurement inaccuracies on P50 results.

Conclusions:

The proposed method offers a practical approach to P50 assessment.
Understanding the impact of measurement errors is vital for reliable P50 determination.

Related Experiment Videos