Recurrent molar pregnancy after ovulation induction and repeat ovulation induction. A case report

Area of Science:

• Reproductive Endocrinology
• Gynecologic Oncology
• Medical Ethics

Background:

• Ovulation induction is associated with a low incidence of hydatidiform mole.
• Patients with prior molar pregnancies have an elevated risk of recurrence.
• Recurrent molar pregnancies can exhibit increasingly severe histologic features.

Observation:

• A 38-year-old woman experienced three consecutive hydatidiform moles following ovulation induction with clomiphene citrate and gonadotropins.
• This represents a unique case of recurrent molar pregnancies without intervening normal intrauterine pregnancies.
• The patient underwent repeat ovulation induction after providing informed consent.

Findings:

• The patient developed three consecutive molar pregnancies, a rare occurrence.
• This case is the first documented instance of three consecutive molar pregnancies after ovulation induction without a normal pregnancy.
• Histologic characteristics of the molar gestations may worsen with recurrence.

Implications:

• Repeat ovulation induction in patients with a history of molar pregnancy presents persistent ethical dilemmas.
• Careful patient counseling regarding the risks of recurrent molar disease is crucial.
• Further research may be needed to understand the mechanisms and management of recurrent molar pregnancies post-ovulation induction.