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Related Concept Videos

Structural Isomerism02:34

Structural Isomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...
Valence Bond Theory02:42

Valence Bond Theory

Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
Colors and Magnetism03:02

Colors and Magnetism

Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human eye.
DNA Topoisomerases02:02

DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types.  Type I...
Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...

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Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
12:19

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks

Published on: November 10, 2016

Bridged cobalt amine complexes induce DNA conformational changes effectively

C Bauer1, A H Wang

  • 1Department of Chemistry, University of Illinois at Urbana-Champaign 61801, USA.

Journal of Inorganic Biochemistry
|October 23, 1997
PubMed
Summary
This summary is machine-generated.

Bridged cobalt(III)pentaamine complexes effectively induce B-DNA to A-DNA and B-DNA to Z-DNA transitions. These novel metal compounds show enhanced DNA conformational change capabilities compared to cobalt(III) hexaamine ions.

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Synthetic Condensates and Cell-Like Architectures from Amphiphilic DNA Nanostructures

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Area of Science:

  • Coordination Chemistry
  • Biophysical Chemistry
  • Molecular Biology

Background:

  • Cobalt(III) hexaamine ions ([Co(NH3)6]3+) induce B- to A-DNA or B- to Z-DNA transitions.
  • Specific interactions occur between [Co(NH3)6]3+ amines and DNA atoms in A-DNA or Z-DNA forms.

Purpose of the Study:

  • Synthesize imidazole-bridged Co(III)pentaamine complexes.
  • Investigate their effectiveness in inducing DNA conformational transitions.
  • Compare their efficacy to [Co(NH3)6]3+.

Main Methods:

  • Synthesis of imidazole-bridged Co(III)pentaamine complexes.
  • Circular dichroism (CD) spectroscopy for DNA titration studies.
  • Nuclear Magnetic Resonance (NMR) spectroscopy for structural analysis.

Main Results:

  • One bridged Co(III)pentaamine complex showed greater efficacy than [Co(NH3)6]3+ in inducing B- to A-DNA transition.
  • Both bridged complexes efficiently induced Z-DNA formation in specific DNA sequences.
  • NMR studies confirmed the B- to A-DNA conversion.

Conclusions:

  • Bridged Co(III)pentaamine complexes enhance DNA conformational transitions.
  • These complexes are more effective than [Co(NH3)6]3+.
  • Bridged Co(III)pentaamine complexes show potential as agents for studying nucleic acid structures.