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Related Experiment Videos

Decrease in forces responsible for diastolic suction during acute coronary occlusion

S P Bell1, J Fabian, M W Watkins

  • 1Cardiology Unit, College of Medicine, University of Vermont, Burlington, USA.

Circulation
|October 23, 1997
PubMed
Summary
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Acute coronary occlusion rapidly reduces left ventricular (LV) suction forces. This loss of restoring forces, independent of end-systolic volume (ESV), may cause diastolic dysfunction during ischemia.

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Mechanics
  • Ischemic Heart Disease

Background:

  • Left ventricular (LV) restoring forces drive diastolic suction.
  • These forces depend on end-systolic volume (ESV) and systolic deformation.
  • Acute coronary occlusion's effect on these forces was unknown.

Purpose of the Study:

  • To test if acute coronary occlusion reduces LV restoring forces.
  • To investigate the impact on suction mechanisms.

Main Methods:

  • Acute coronary occlusion was induced in 10 open-chest dogs.
  • Left atrial (LA) pressure was clamped during systole to create nonfilling diastoles.
  • The fully relaxed LV pressure-volume relation (FRPVR) was analyzed using a conductance catheter.

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Main Results:

  • Acute coronary occlusion caused an upward shift in the FRPVR.
  • Negative fully relaxed pressure (FRP), indicating restoring forces, decreased significantly.
  • FRP changed from -1.1+/-1.1 mm Hg to 0.2+/-1.2 mm Hg at matched ESVs (P<.05).

Conclusions:

  • Acute coronary occlusion rapidly diminishes the forces responsible for LV suction.
  • This reduction is independent of ESV.
  • The findings suggest a mechanism for ischemic diastolic dysfunction.