Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect on dissolution from halving methylphenidate extended-release tablets

J Erramouspe1, E J Jarvi

  • 1Department of Pharmacy Practice and Administrative Sciences, College of Pharmacy, Idaho State University, Pocatello 83209, USA.

The Annals of Pharmacotherapy
|October 24, 1997
PubMed
Summary

Cutting methylphenidate extended-release tablets in half significantly increased in vitro dissolution, particularly within the first two hours. However, the overall differences were not substantial, suggesting it may be a viable method for dose adjustment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Piezoelectric quartz crystal biosensors.

Talanta·2008
Same author

A piezoelectric method for monitoring formaldehyde induced crosslink formation between poly-lysine and poly-deoxyguanosine.

Talanta·2008
Same author

DNA-protein cross-link formation in Burkitt lymphoma cells cultured with benzaldehyde and the sedative paraldehyde.

Drug and chemical toxicology·2007
Same author

Elevated DNA-protein cross-links in red blood cells of German carp, Cyprinus carpio, from the Lower Passaic River, New Jersey, USA.

Bulletin of environmental contamination and toxicology·2005
Same author

Intramuscular ceftriaxone in the treatment of childhood meningitis due to Haemophilus influenzae type F.

The Annals of pharmacotherapy·2001
Same author

treatment and prevention of otitis media.

The Annals of pharmacotherapy·2001

Area of Science:

  • Pharmacology
  • Pharmaceutical Sciences
  • Drug Delivery

Background:

  • Methylphenidate is a central nervous system stimulant used to treat ADHD.
  • Extended-release formulations are designed for sustained drug delivery.
  • Dosage adjustments are common in clinical practice.

Purpose of the Study:

  • To evaluate the impact of halving methylphenidate extended-release tablets on their in vitro dissolution profile.
  • To compare the dissolution of whole versus halved tablets for both branded and generic formulations.

Main Methods:

  • Utilized US Pharmacopeia dissolution methods for Ritalin-SR and generic methylphenidate extended-release tablets.
  • Tested tablets in both whole and halved conditions.
  • Analyzed methylphenidate content using High-Performance Liquid Chromatography (HPLC) at various time points.

Related Experiment Videos

Main Results:

  • Halving tablets led to a statistically significant increase in cumulative dissolution starting at 15 minutes.
  • Maximum dissolution differences between whole and halved tablets were observed at 2 hours (e.g., 57% vs. 74% for Ritalin-SR).
  • Dissolution profiles became parallel after 2 hours, with no significant difference by 7 hours.

Conclusions:

  • Statistically significant differences in in vitro dissolution exist when methylphenidate extended-release tablets are halved.
  • The absolute differences in dissolution are relatively small.
  • Halving these tablets could be a clinically acceptable method for minor dose adjustments.