Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

'Vascular depression' hypothesis

G S Alexopoulos1, B S Meyers, R C Young

  • 1Cornell Institute of Geriatric Psychiatry, Cornell University Medical College, White Plains, NY, USA.

Archives of General Psychiatry
|October 24, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Brain charts for the human lifespan.

Nature·2022
Same author

Brain charts for the human lifespan.

Nature·2022
Same author

Physical Exercise for Late-Life Major Depression.

Focus (American Psychiatric Publishing)·2021
Same author

Stabilization treatment of remitted psychotic depression: the STOP-PD study.

Acta psychiatrica Scandinavica·2018
Same author

Physical exercise for late-life major depression.

The British journal of psychiatry : the journal of mental science·2015
Same author

Cognitive control, reward-related decision making and outcomes of late-life depression treated with an antidepressant.

Psychological medicine·2015
Same journal

Reviewers Who Completed a Review During 2011.

Archives of general psychiatry·2017
Same journal

Conflicts of interest-reply.

Archives of general psychiatry·2013
Same journal

Epidemiologic evidence concerning the bereavement exclusion in major depression-reply.

Archives of general psychiatry·2013
Same journal

This month in archives of general psychiatry.

Archives of general psychiatry·2013
Same journal

About this journal.

Archives of general psychiatry·2013
Same journal

This month in archives of general psychiatry.

Archives of general psychiatry·2013
See all related articles

Cerebrovascular disease may contribute to geriatric depression. This "vascular depression" hypothesis links brain lesions to depressive symptoms, suggesting new treatment avenues for older adults.

Area of Science:

  • Geriatric psychiatry
  • Neurology
  • Vascular medicine

Background:

  • Comorbidity of depression and vascular disease is common in the elderly.
  • Vascular risk factors are prevalent in geriatric depression.
  • Ischemic brain lesions correlate with specific behavioral symptoms.

Purpose of the Study:

  • To propose the
  • vascular depression
  • hypothesis linking cerebrovascular disease to geriatric depressive syndromes.
  • To explore the role of prefrontal system disruption in vascular depression.
  • To suggest avenues for clinical research and therapeutic interventions.

Main Methods:

  • Review of existing literature on cerebrovascular disease and depression.

Related Experiment Videos

  • Hypothesizing mechanisms involving ischemic lesions and prefrontal system dysfunction.
  • Examining the association between lesion location, brain dysfunction, and depressive presentation.

    • Main Results:

    • Evidence supports the link between vascular disease and depression in the elderly.
    • Ischemic lesions, particularly in prefrontal areas, are implicated in vascular depression.
    • A threshold of accumulated lesions may be necessary to trigger depressive syndromes.

    Conclusions:

    • Cerebrovascular disease is a potential predisposing, precipitating, or perpetuating factor in geriatric depression.
    • The vascular depression hypothesis offers a framework for further research and clinical trials.
    • Pharmacological interventions targeting cerebrovascular disease may impact vascular depression outcomes.