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Multiple pulmonary nodules in association with pyoderma gangrenosum
I Kasuga1, N Yanagisawa, C Takeo
1First Department of Internal Medicine, Tokyo Medical College, Japan.
Respiratory Medicine
|October 24, 1997
Summary
Pyoderma gangrenosum can affect the lungs, causing multiple lesions. Steroid treatment effectively controlled these pulmonary infiltrates in a unique case.
Area of Science:
- Pulmonary Medicine
- Dermatology
- Pathology
Background:
- Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis.
- Pulmonary involvement in PG is exceptionally uncommon.
- This case highlights a rare presentation of PG with significant lung pathology.
Observation:
- A patient presented with extensive skin lesions of pyoderma gangrenosum.
- Radiographic imaging revealed bilateral, peripherally located pulmonary nodules.
- Lung biopsy demonstrated chronic inflammation with neutrophil and lymphocyte infiltration, mirroring skin lesions.
Findings:
- The patient was diagnosed with multiple aseptic nodules associated with pyoderma gangrenosum.
- Pulmonary lesions showed significant improvement with prednisolone treatment.
- Histological findings in the lung were consistent with the inflammatory process seen in the skin.
Implications:
- This case expands the understanding of potential extragenital manifestations of pyoderma gangrenosum.
- Early recognition and treatment of pulmonary involvement in PG are crucial.
- Systemic corticosteroid therapy is indicated for managing pulmonary lesions in pyoderma gangrenosum.