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Related Experiment Videos

Telomerase, checkpoints and cancer

C B Harley1, S W Sherwood

  • 1Geron Corporation, Menlo Park, CA 94025, USA.

Cancer Surveys
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Telomere length and telomerase activity are key to cell aging and cancer. Manipulating telomeres offers potential for new anti-cancer therapies by inducing cell death.

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Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Genetics

Background:

  • Telomere dynamics and telomerase activity are crucial in cellular proliferation.
  • Telomere shortening without telomerase leads to senescence, while reactivation causes immortality.
  • These processes are central to understanding aging and cancer development.

Purpose of the Study:

  • To explore the relationship between telomere dynamics, telomerase activity, and cellular aging/cancer.
  • To investigate potential therapeutic strategies targeting telomeres and telomerase.

Main Methods:

  • Analysis of telomere length and telomerase activity in relation to cellular proliferative states.
  • Review of studies on telomere-associated genes in yeast and telomerase inhibition in human tumor cells.

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  • Examination of signaling pathways connecting telomeres to cell cycle regulation.

    • Main Results:

    • Telomere loss correlates with senescence, while telomerase reactivation is linked to immortality.
    • Evidence suggests pathways transduce signals from chromosome structure to cell cycle control.
    • Studies in yeast and human tumor cells demonstrate feasibility of targeting telomeres/telomerase for antiproliferative effects.

    Conclusions:

    • Telomere and telomerase biology offer a new paradigm for aging and cancer research.
    • Targeting telomeres/telomerase shows promise as an antiproliferative therapeutic strategy.
    • Further research is needed to understand cell death mechanisms and potential escape routes.