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Treatment of refractory depression
1Yale University School of Medicine, New Haven, CT, USA.
Depression and Anxiety
|January 1, 1997
Summary
Treating refractory depression requires ensuring adequate medication dosage and duration. Clinicians can then consider evidence-based augmentation strategies or alternative antidepressants for better patient outcomes.
Area of Science:
- Psychiatry and Behavioral Sciences
- Clinical Pharmacology
Background:
- Refractory depression presents a significant clinical challenge.
- Optimal treatment requires careful consideration of dosage and duration.
- A range of augmentation and alternative antidepressant strategies exist.
Purpose of the Study:
- To review evidence for refractory depression treatment strategies.
- To describe the implementation of these strategies.
- To compare the effectiveness of various treatment options.
Main Methods:
- Literature review of augmentation strategies and alternative antidepressants.
- Analysis of evidence supporting treatment efficacy.
- Comparative effectiveness assessment.
Main Results:
- Evidence supports various augmentation and alternative antidepressant strategies.
- Implementation guidelines are provided.
- Comparative data on effectiveness is discussed.
Conclusions:
- Clinicians should first optimize current treatment.
- Augmentation or alternative strategies are viable options for refractory depression.
- A systematic approach aids in selecting the best treatment.