[Febrile eruptions in systemic diseases in children]

D Hamel-Teillac1, C Bodemer

  • 1Service de dermatologie, Hôpital Necker-Enfants malades, Paris.

La Revue Du Praticien
|October 27, 1997
PubMed

Insights

Systemic diseases can cause skin lesions in children. When fever and rash appear, infectious causes are considered first, but persistent symptoms may indicate systemic illness, where skin manifestations are key diagnostic clues.

Area of Science:

  • Pediatrics
  • Dermatology
  • Internal Medicine

Background:

  • Systemic diseases frequently manifest with cutaneous lesions.
  • Differentiating between infectious and systemic causes of pediatric rash and fever is clinically challenging.
  • Cutaneous symptoms can be crucial in diagnosing systemic diseases when initial presentations are non-specific.

Purpose of the Study:

  • To highlight the diagnostic significance of cutaneous lesions in children with systemic diseases.
  • To emphasize the importance of considering systemic illness when infectious disease workup is negative.
  • To guide clinicians in utilizing dermatological findings for accurate diagnosis.

Main Methods:

  • Review of clinical presentations of children with systemic diseases and cutaneous manifestations.
  • Analysis of diagnostic pathways for pediatric rash and fever.
  • Correlation of specific skin lesions with underlying systemic conditions.

Main Results:

  • Cutaneous lesions are common in acute systemic diseases presenting with fever and malaise.
  • Non-specific biological tests may not aid in early diagnosis of systemic diseases.
  • Skin manifestations provide critical clues for identifying the correct diagnosis.

Conclusions:

  • Cutaneous symptoms are invaluable in the diagnosis of systemic diseases in children.
  • Systemic diseases should be suspected in pediatric patients with unexplained rash and fever unresponsive to anti-infective treatments.
  • Dermatological assessment is essential for timely and accurate diagnosis.

Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Types of Fever01:25

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Patterns of Fever01:26

Patterns of Fever

Before understanding the types and patterns of fever, it is essential to know its phases.
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...