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[Inefficacy of exchange-transfusion in case of a methotrexate poisoning]
S Bénézet1, E Chatelut, H Bagheri
1Service de pharmacologie clinique, Centre Midi-Pyrénées de pharmacovigilance, de pharmacoépidémiologie et d'informations sur le médicament, Faculté de médecine, Toulouse, France.
Bulletin Du Cancer
|August 1, 1997
Abstract:
We report on a case of methotrexate (MTX) intoxication occurring in a 19-year-old man treated for a leukemia. Exchange-transfusion (ET) was performed in attempt to remove the MTX from the body. This exchange-transfusion was unable to decrease the MTX plasma concentration. This inefficacy of ET in MTX intoxication is in contradiction with previously reported recommendations. However, this result is easily explained by MTX pharmacokinetics parameters.