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[Protein kinase C and tumorigenic potential]
1Laboratoire de biologie cellulaire, INSERM U. 402, Faculté de médecine Saint-Antoine, Paris, France.
Bulletin Du Cancer
|August 1, 1997
Summary
Protein kinase C (PKC) comprises 11 isoforms involved in cancer. Studies exploring PKC isoform roles in growth signaling deregulation, particularly in colorectal cancer, have advanced understanding of the PKC-cancer relationship.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Context:
- Protein kinase C (PKC) is a family of 11 isoforms with diverse properties.
- Deregulation of growth signaling pathways is a hallmark of carcinogenesis.
- Understanding the specific roles of PKC isoforms in cancer is crucial.
Purpose:
- To review the advancements in understanding the role of specific PKC isoforms in carcinogenesis.
- To highlight research on the PKC-cancer relationship, focusing on colorectal cancer.
Summary:
- This review consolidates findings on PKC isoforms and their involvement in cancer development.
- Overexpression of specific PKC isoforms in cellular models has been instrumental in elucidating their functions.
- Key results concerning the PKC-cancer link, especially in colorectal cancer, are presented.
Impact:
- Provides a comprehensive overview of PKC isoform functions in cancer.
- Identifies key strategies and findings in PKC-cancer research.
- Offers insights into the molecular mechanisms of carcinogenesis driven by PKC.