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[Protein kinase C and tumorigenic potential]
1Laboratoire de biologie cellulaire, INSERM U. 402, Faculté de médecine Saint-Antoine, Paris, France.
Abstract:
Initially described as a unique entity, protein kinase C (PKC) is now represented by a family of 11 isoforms which differ in their structural and biochemical properties as well as in their tissular distribution, subcellular localization and substrate specificity. So far a lot of studies have attempted to approach the role of each of these PKC isoforms in the deregulation of growth signaling that leads to carcinogenesis. Among the various strategies developed, the surexpression of specific isoforms in different cellular models is the strategy which led to major advances as concern the PKC-cancer relationship. This review reports the main results obtained in this field especially in that of colorectal cancer.
Insights
Protein kinase C (PKC) comprises 11 isoforms involved in cancer. Studies exploring PKC isoform roles in growth signaling deregulation, particularly in colorectal cancer, have advanced understanding of the PKC-cancer relationship.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Context:
- Protein kinase C (PKC) is a family of 11 isoforms with diverse properties.
- Deregulation of growth signaling pathways is a hallmark of carcinogenesis.
- Understanding the specific roles of PKC isoforms in cancer is crucial.
Purpose:
- To review the advancements in understanding the role of specific PKC isoforms in carcinogenesis.
- To highlight research on the PKC-cancer relationship, focusing on colorectal cancer.
Summary:
- This review consolidates findings on PKC isoforms and their involvement in cancer development.
- Overexpression of specific PKC isoforms in cellular models has been instrumental in elucidating their functions.
- Key results concerning the PKC-cancer link, especially in colorectal cancer, are presented.
Impact:
- Provides a comprehensive overview of PKC isoform functions in cancer.
- Identifies key strategies and findings in PKC-cancer research.
- Offers insights into the molecular mechanisms of carcinogenesis driven by PKC.