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Bile flow and composition in preterm, term and infant baboons

R Bhat1, G Chari, J Meller

  • 1Department of Pediatrics, University of Illinois, Chicago 60612, USA. Rama.Bhat@UIC.edu

Biology of the Neonate
|January 1, 1997
PubMed

Insights

Bile flow and bile acid excretion mature significantly in baboons after birth. This study shows baboons are a suitable model for studying postnatal hepatic excretory function development.

Area of Science:

  • Hepatology
  • Developmental Biology
  • Physiology

Background:

  • Bile composition, flow, and choleretic effects undergo maturational changes.
  • Understanding these changes is crucial for assessing hepatic excretory function.

Purpose of the Study:

  • To investigate maturational changes in bile composition and flow in baboons.
  • To evaluate the choleretic effects of sodium taurocholate and secretin at different postnatal ages.

Main Methods:

  • Studied preterm, term, 7-day, and 60-day-old baboons.
  • Determined canalicular bile flow using 14C-erythritol clearance.
  • Assessed gallbladder volume, bile flow, and bile acid excretion.

Main Results:

  • Gallbladder volume and bile flow significantly increased with postnatal age.
  • Total bile acid excretion also showed a significant increase.
  • Sodium taurocholate and secretin demonstrated significant choleretic effects across all age groups.

Conclusions:

  • Bile flow and bile acid excretion are immature in preterm and term baboons compared to older baboons.
  • Baboons serve as a valuable model for studying postnatal hepatic excretory function maturation.
Abstract

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