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Miconazole genotoxicity in mice

N H Hassan1

  • 1Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.

Journal of Applied Toxicology : JAT
|October 27, 1997
PubMed
Summary

Miconazole (MC) demonstrated genotoxic effects in mice, causing significant, dose-dependent chromosomal damage in bone marrow and germ cells. Sperm head abnormalities also increased significantly following MC exposure.

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Area of Science:

  • Toxicology
  • Genetics
  • Reproductive Toxicology

Background:

  • Miconazole (MC) is an antifungal medication with a known safety profile.
  • However, its potential genotoxic effects on mammalian somatic and germ cells require thorough investigation.

Purpose of the Study:

  • To evaluate the genotoxic potential of miconazole (MC) in mouse bone-marrow cells and primary spermatocytes.
  • To assess the induction of chromosomal aberrations and sperm head abnormalities following MC exposure.

Main Methods:

  • Mice were administered miconazole (MC) at doses of 0.1, 0.5, and 1 mg/animal via acute and subacute treatment protocols.
  • Chromosomal aberrations were analyzed in bone-marrow cells and primary spermatocytes.
  • Sperm head morphology was examined after five days of successive MC treatment.

Main Results:

  • Both acute and subacute miconazole (MC) treatments induced statistically significant, dose-dependent chromosomal aberrations in mouse somatic and germ cells.
  • A significant, dose-dependent increase in morphological sperm head abnormalities was observed following MC administration.

Conclusions:

  • Miconazole (MC) exhibits genotoxic activity in mice.
  • The findings suggest that miconazole poses a risk to both somatic and germ cell genetic integrity.

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