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The anal transitional zone. Location and extent

C Fenger

    Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology
    |September 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    The anal transitional zone (ATZ) extends further than previously thought, from 6 mm below to 20 mm above the dentate line. This finding redefines the anatomical boundaries for anal canal carcinomas.

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    Area of Science:

    • Gastroenterology
    • Surgical Pathology
    • Anorectal Anatomy

    Background:

    • The precise anatomical boundaries of the anal transitional zone (ATZ) are crucial for understanding anal canal pathology.
    • Previous definitions of the ATZ may not fully encompass the variability observed in vivo.

    Purpose of the Study:

    • To accurately determine the location and extent of the anal transitional zone (ATZ).
    • To correlate ATZ variations with the anatomical origins of anal canal carcinomas.

    Main Methods:

    • Macroscopic assessment using whole-mount staining with Alcian-dyes.
    • Conventional histological examination of tissue samples.
    • Analysis of specimens from the age group typical for anal canal carcinomas.

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    Main Results:

    • Epithelial variants within the ATZ were observed over a broader area than previously reported, ranging from 6 mm below to 20 mm above the dentate line.
    • Significant variations in the location and extent of the ATZ were documented.
    • Mature squamous epithelium was frequently identified high within the anal canal.

    Conclusions:

    • The study proposes a revised definition for anal canal carcinomas, suggesting they be classified as tumors located within 2 cm above the dentate line.
    • Findings highlight the importance of considering the extended ATZ in the diagnosis and classification of anal canal tumors.
    • The variability of the ATZ has significant implications for surgical and oncological management strategies.