Related Experiment Video
Updated: Aug 17, 2026

Purification and Visualization of Lipopolysaccharide from Gram-negative Bacteria by Hot Aqueous-phenol Extraction
Published on: May 28, 2012
[Role of bacterial lipopolysaccharides in human diseases: evolution of outlook]
Abstract:
The authors propose a new conception of the role of bacterial lipopolysaccharides (LPS) in human illnesses. Being a structural component of a great variety of gram-negative bacteria, upon the entrance of human body bacterial LPS serve as a biological signal indicative of bacterial invasion. This activates body defenses striving to limit the inflammatory focus, to arrest dissemination of the bacteria and their cleaning up. Such response of the body is feasible only in case of adequate function of the body defenses. Functional failure of the latter leads to inadequate response of the body which can not control systemic inflammation with polyorganic lesions.
Related Concept Videos
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Biosynthesis of Lipids
Formation of Lipopolysaccharides
Colonisation of Pathogens
Bacterial Toxins
Determinants of Bacterial Pathogenicity and Virulence

