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[Current problems of regulation of adrenocortical function]
1Institute of Endocrynology of Metabolism AMN of Ukraine, Kiev.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
|January 1, 1997
Summary
Adrenocorticotropic hormone (ACTH) regulates corticosteroid secretion during acute stress, while adrenal hypertrophy and factors like prolactin are key in chronic stress responses. The Steroidogenic Acute Regulatory Protein (STAR) is crucial for cholesterol transport in steroidogenesis.
Area of Science:
- Endocrinology
- Molecular Biology
- Stress Physiology
Context:
- Corticosteroid secretion is vital for stress adaptation.
- Regulation involves complex hormonal and cellular mechanisms.
- Understanding these pathways is key to managing stress-related disorders.
Purpose:
- To analyze current data on corticosteroid secretion regulation.
- To elucidate the roles of ACTH, STAR, and other factors in stress.
- To explore mechanisms of adrenal adaptation under acute and chronic stress.
Summary:
- Adrenocorticotropic hormone (ACTH) drives acute corticosteroid synthesis by facilitating cholesterol transport to mitochondria via the Steroidogenic Acute Regulatory Protein (STAR).
- Chronic stress involves adrenal hypertrophy and modulation by neuropeptides, cytokines, and growth factors.
- Prolactin acts as a mitogenic factor, influencing adrenal function and proliferation during chronic stress.
Impact:
- Provides a comprehensive overview of corticosteroid regulation.
- Highlights key molecular players like STAR in steroidogenesis.
- Offers insights into the physiological basis of stress response and adrenal adaptation.