Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structures of Solids02:22

Structures of Solids

18.0K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
18.0K
Metallic Solids02:37

Metallic Solids

20.8K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.8K
Network Covalent Solids02:18

Network Covalent Solids

16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
Molecular and Ionic Solids02:54

Molecular and Ionic Solids

20.2K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.2K
Stereotype Content Model02:16

Stereotype Content Model

15.5K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
15.5K
Molecular Comparison of Gases, Liquids, and Solids02:26

Molecular Comparison of Gases, Liquids, and Solids

55.4K
Particles in a solid are tightly packed together (fixed shape) and often arranged in a regular pattern; in a liquid, they are close together with no regular arrangement (no fixed shape); in a gas, they are far apart with no regular arrangement (no fixed shape). Particles in a solid vibrate about fixed positions (cannot flow) and do not generally move in relation to one another; in a liquid, they move past each other (can flow) but remain in essentially constant contact; in a gas, they move...
55.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2015
Same author

Transduction of human dendritic cells with a recombinant modified vaccinia Ankara virus encoding MUC1 and IL-2.

Cancer immunology, immunotherapy : CII·2001
Same author

Cationic lipid-mediated gene transfer: current concepts.

Current opinion in molecular therapeutics·2001
Same author

Phase II study of direct intralesional gene transfer of allovectin-7, an HLA-B7/beta2-microglobulin DNA-liposome complex, in patients with metastatic melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2001
Same author

Preclinical antitumor activity of the azonafide series of anthracene-based DNA intercalators.

Anti-cancer drugs·2001
Same author

A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors.

Cancer chemotherapy and pharmacology·2001

Related Experiment Video

Updated: Feb 9, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

12.3K

Mononuclear cell content of human solid tumors

E M Hersh, G M Mavligit, J U Gutterman

    Medical and Pediatric Oncology
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Researchers analyzed mononuclear cells from human solid tumors to understand tumor immunity. They found that primary tumors had more lymphocytes than metastatic ones, though some metastatic tumors showed stronger immune responses.

    More Related Videos

    Analysis of Side Population in Solid Tumor Cell Lines
    06:26

    Analysis of Side Population in Solid Tumor Cell Lines

    Published on: February 23, 2021

    4.8K
    Predictive Immune Modeling of Solid Tumors
    08:50

    Predictive Immune Modeling of Solid Tumors

    Published on: February 25, 2020

    7.6K

    Related Experiment Videos

    Last Updated: Feb 9, 2026

    Enhancing Tumor Content through Tumor Macrodissection
    10:04

    Enhancing Tumor Content through Tumor Macrodissection

    Published on: February 12, 2022

    12.3K
    Analysis of Side Population in Solid Tumor Cell Lines
    06:26

    Analysis of Side Population in Solid Tumor Cell Lines

    Published on: February 23, 2021

    4.8K
    Predictive Immune Modeling of Solid Tumors
    08:50

    Predictive Immune Modeling of Solid Tumors

    Published on: February 25, 2020

    7.6K

    Area of Science:

    • Immunology
    • Oncology
    • Cell Biology

    Background:

    • Understanding the immune microenvironment of solid tumors is crucial for developing effective cancer therapies.
    • Mononuclear cells, including lymphocytes and macrophages, play a significant role in anti-tumor immunity.

    Purpose of the Study:

    • To determine the cellular content and functional capacity of mononuclear cells within human solid tumors.
    • To compare lymphocyte and macrophage populations and their functions in primary versus metastatic tumors.

    Main Methods:

    • Solid tumors (primary and metastatic) were processed to isolate mononuclear cells.
    • Cellular content was analyzed via light microscopy.
    • Lymphocyte function was assessed through blastogenesis assays using various mitogens and antigens.

    Main Results:

    • A median yield of 7.8 x 10^6 lymphocytes/gram and 0.35 x 10^6 macrophages/gram was obtained.
    • Significant lymphocyte responses to mitogens/antigens were observed in 31-40% of tumor preparations.
    • Primary tumors had a higher percentage of lymphocytes (13.5%) compared to metastatic tumors (5%), but some metastatic tumors exhibited enhanced lymphocyte responses.

    Conclusions:

    • Direct analysis of tumor-infiltrating lymphocytes provides insights into human tumor immunity.
    • Differences in lymphocyte content and function exist between primary and metastatic solid tumors.
    • Further investigation into tumor-infiltrating lymphocytes may aid in understanding and manipulating anti-tumor immune responses.