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Published on: February 23, 2014
Peripheral nerves regenerated in familial amyloid polyneuropathy after liver transplantation
S Ikeda1, Y Takei, N Yanagisawa
1Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.
Background:
Liver transplantation holds promise as a treatment for familial amyloid polyneuropathy.
Objective:
To determine whether peripheral nerves regenerate in patients with familial amyloid polyneuropathy after liver transplantation.
Design:
Case report.
Setting:
University hospital in Matsumoto, Japan.
Patient:
A 34 year-old-women with familial amyloid polyneuropathy who had liver transplantation and showed marked clinical improvement 3 years after surgery.
Measurements:
Histopathologic examination and morphometric analysis of biopsy specimens taken from sural nerves.
Results:
Diffuse fiber loss and amyloid deposits were seen in a biopsy specimen of the left sural nerve obtained before liver transplantation (total number of myelinated fibers, 1326/mm2 of the endoneurial area). In the biopsy specimen of the right sural nerve, which was obtained 3 years after transplantation, amyloid deposits remained but the number of myelinated fibers was markedly increased (total number of myelinated fibers, 4740/mm2).
Conclusion:
Peripheral nerves regenerated in a patient with familial amyloid polyneuropathy after liver transplantation.
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