Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oldest-old healthy brain function. The genomic potential

J A Kaye1

  • 1Department of Neurology, Oregon Health Sciences University, Portland, USA.

Archives of Neurology
|October 28, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world outcomes in patients with ALK-positive non-small cell lung cancer treated with crizotinib.

Current oncology (Toronto, Ont.)·2018
Same author

Economic Burden of Melanoma in Three European Countries: A Retrospective Observational Study.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
Same author

Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures.

NeuroImage. Clinical·2015
Same author

Prospective, observational study of plasma-derived factor VIII/von Willebrand factor in immune tolerance induction: the PRISM registry.

Haemophilia : the official journal of the World Federation of Hemophilia·2015
Same author

In-home walking speeds and variability trajectories associated with mild cognitive impairment.

Neurology·2012
Same author

Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging.

Neurology·2011
Same journal

Incorrect Table Entries and Word.

Archives of neurology·2016
Same journal

IDEAL for CCSVI Research-Reply.

Archives of neurology·2013
Same journal

Atlas of Inherited Metabolic Diseases, 3rd ed.

Archives of neurology·2013
Same journal

Error in byline: in heterogeneity of coenzyme q10 deficiency: patient study and literature review.

Archives of neurology·2013
Same journal

This month in archives of neurology.

Archives of neurology·2013
Same journal

About this journal.

Archives of neurology·2013
See all related articles

The number of oldest-old adults is rising, increasing dementia risk. Genetic research offers hope for delaying cognitive decline in aging brains.

Area of Science:

  • Gerontology
  • Neuroscience
  • Genetics

Background:

  • The population of individuals over 85 years old is projected to grow significantly in the coming decades.
  • The oldest-old demographic is particularly susceptible to age-related disabilities, often stemming from nervous system changes.
  • Dementia is a prevalent cognitive failure in advanced age, impacting a majority of those reaching the maximum human lifespan.

Purpose of the Study:

  • To explore the potential of genetic factors in modifying or delaying the onset of dementia in the oldest-old.
  • To identify gene families as potential targets for interventions aimed at mitigating late-life cognitive decline.

Main Methods:

  • Review of recent genetic studies on aging and Alzheimer disease.
  • Analysis of evidence suggesting susceptibility genes influence the timing of cognitive impairment.

Related Experiment Videos

Main Results:

  • Evidence indicates that specific susceptibility genes may play a role in delaying the onset of late-life brain failure.
  • These genetic factors represent a promising avenue for therapeutic strategies.

Conclusions:

  • Dementia may be considered a normal aspect of aging for the oldest-old, given its prevalence.
  • Targeting identified gene families holds potential for developing interventions to significantly delay the onset of dementia.