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Functional bioinformatics: the cellular response database

J Sorace1, K Canfield, S Russell

  • 1Department of Information Systems, University of Maryland Baltimore County, Baltimore, Maryland, USA. jmsorace@ ix.netcom.com

Frontiers in Bioscience : a Journal and Virtual Library
|October 29, 1997
PubMed
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Biological scientists can now leverage the Cellular Response Database to analyze gene expression changes. This bioinformatics tool links cell types, genes, and stimuli, aiding hypothesis generation and biological discovery.

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Genomics

Background:

  • Biological research generates vast amounts of data, requiring structured information systems.
  • Current databases primarily store protein and nucleic acid sequences.
  • There is a need for databases that capture functional cellular responses to stimuli.

Purpose of the Study:

  • To introduce the Cellular Response Database for storing and querying functional genomic data.
  • To support the generation of biological hypotheses from cellular response information.
  • To facilitate the interpretation of complex biological data for new knowledge discovery.

Main Methods:

  • Development of a novel database, the Cellular Response Database.
  • Implementation of query functions linking cell types, expressed genes, and inducers.

Related Experiment Videos

  • Design for flexibility to store diverse experimental data, including cytotoxicity and immunoassay results.

    • Main Results:

    • The database successfully stores functional information on cellular gene expression changes.
    • Query capabilities enable linking of cell types, genes, and stimuli.
    • The system accommodates a wide range of experimental data types.

    Conclusions:

    • The Cellular Response Database provides a valuable resource for biological scientists.
    • It enhances the ability to generate hypotheses and discover new biological knowledge.
    • The database structure supports complex, information-intensive biological queries.