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Related Experiment Videos

Recurrent excitatory postsynaptic potentials induced by synchronized fast cortical oscillations

M A Whittington1, R D Traub, H J Faulkner

  • 1Department of Physiology and Biophysics, Imperial College School of Medicine at St. Mary's, London W2 1PG, United Kingdom. m.whittington@sm.ic.ac.uk

Proceedings of the National Academy of Sciences of the United States of America
|October 29, 1997
PubMed
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Synchronous gamma oscillations in the brain can strengthen neural connections for over an hour. This process, observed in the hippocampus, may form the basis for memory storage and retrieval.

Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • Gamma frequency oscillations (20-70 Hz) are observed during novel sensory stimulation, with synchronized activity over long distances.
  • Synchronization has been theorized to represent the coactivation of visual field areas by extended objects.
  • Intracortical mechanisms, such as interneuron spike doublet firing, can explain long-range synchrony.

Purpose of the Study:

  • To investigate the causal relationship between synchronous gamma oscillations and synaptic plasticity.
  • To explore the role of these oscillations in forming and retrieving neuronal assemblies for memory.

Main Methods:

  • Recording of synchronous gamma oscillations in hippocampal area CA1.
  • Measurement of excitatory postsynaptic potential (EPSP) amplitude and action potential afterhyperpolarization size.

Related Experiment Videos

  • Observation of synaptic potentiation lasting over 1 hour.

    • Main Results:

    • Synchronous gamma oscillations (>400 ms) led to long-lasting potentiation of recurrent excitatory synapses.
    • An increase in EPSP amplitude and action potential afterhyperpolarization size was observed.
    • The induced EPSPs stabilized and synchronized a prolonged beta frequency (10-25 Hz) oscillation.
    • Changes in EPSP size were not expressed during non-oscillatory periods but reappeared during subsequent gamma oscillations.

    Conclusions:

    • Synchronous gamma oscillations induce lasting synaptic changes, serving as a substrate for memory.
    • This phenomenon provides a dynamical mechanism for the storage and retrieval of stimulus-specific neuronal assemblies.
    • The expression of oscillation-induced EPSPs can modulate the synchronization of spatially separated neuronal sites.