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Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
Precocious pseudopuberty due to a granulosa cell tumour in a seven-month-old female
F J Cameron1, I Scheimberg, R Stanhope
1Department of Endocrinology, Great Ormond Street Hospital for Sick Children NHS Trust, London, UK.
Insights
A rare juvenile granulosa cell tumor caused precocious puberty in an infant girl. Diagnosis was challenging due to inconsistent pubertal signs and slightly elevated alpha-fetoprotein levels.
Area of Science:
- Pediatric Endocrinology
- Gynecologic Oncology
- Pathology
Background:
- Juvenile granulosa cell tumors (JGCTs) are rare ovarian neoplasms in children.
- Early diagnosis and treatment are crucial for favorable outcomes.
Observation:
- A case of JGCT presenting as pseudopuberty in an infant female is described.
- Clinical signs of puberty were inconsistent.
- Marginally elevated serum alpha-fetoprotein levels complicated diagnosis.
Findings:
- Histological examination of the resected tumor confirmed JGCT.
- Positive MIC2 antibody binding to tumor cells supported the diagnosis.
Implications:
- This case highlights the importance of considering rare ovarian tumors in infants with precocious puberty.
- Accurate histological and immunohistochemical analysis is vital for diagnosis.
- Early intervention in JGCT can lead to better prognosis.
Abstract:
We describe a juvenile granulosa cell tumour resulting in pseudopuberty in an infant female. The progression of the clinical signs of puberty were non-consonant and the diagnosis was complicated by marginally elevated serum alpha-fetoprotein levels. The histological appearance of the resected tumour and binding of MIC2 antibody to tumour cells confirmed the diagnosis.
