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Cell-cell communication in gram-positive bacteria

G M Dunny1, B A Leonard

  • 1Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455, USA. gary-d@biosci.cbs.umn.edu

Annual Review of Microbiology
|January 1, 1997
PubMed
Summary
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Gram-positive bacteria use peptide-based cell-to-cell communication (quorum sensing) to regulate vital functions. These signals, active at low concentrations, control virulence, gene transfer, and antibiotic production.

Area of Science:

  • Microbiology
  • Bacterial Physiology
  • Molecular Biology

Background:

  • Gram-positive bacteria utilize cell-to-cell communication mediated by extracellular signal molecules.
  • These signaling molecules are predominantly peptides or modified peptides.
  • This communication regulates crucial bacterial processes.

Purpose of the Study:

  • To elucidate the mechanisms and significance of peptide-based cell-to-cell communication in gram-positive bacteria.
  • To highlight the role of these signaling molecules in regulating bacterial behavior.

Main Methods:

  • Analysis of extracellular signal molecules in gram-positive bacteria.
  • Investigation of signal processing mechanisms (transduction or import).
  • Assessment of biological activity at low signal concentrations.

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Main Results:

  • Extracellular signaling molecules, primarily peptides, mediate cell-to-cell communication.
  • Signal processing involves cytoplasmic membrane transduction or intracellular interaction.
  • Biological activity is observed at nanomolar or lower signal concentrations.

Conclusions:

  • Peptide-based signaling is a key regulatory mechanism in gram-positive bacteria.
  • This communication influences bacterial virulence, gene transfer, and antibiotic production.
  • Understanding these pathways is crucial for controlling microbial processes.