Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Three-dimensional reconstructions of the developing forebrain in rat embryos

S A Bayer1, X Zhang, R J Russo

  • 1Department of Biology, Indiana-Purdue University, Indianapolis 46202, USA.

Neuroimage
|November 1, 1994
PubMed
Summary

Forebrain development in rat embryos shows significant growth and structural changes from embryonic day 12 to 21. Ventricular and neuroepithelial volumes expand then contract, while parenchyma volume consistently increases, highlighting differential growth between telencephalon and diencephalon.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response of leaf internal CO<sub>2</sub> concentration and intrinsic water-use efficiency in Norway spruce to century-long gradual CO<sub>2</sub> elevation.

Photosynthetica·2025
Same author

Neurogenesis in the rat neostriatum.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2014
Same author

Neurogenesis in the olfactory tubercle and islands of Calleja in the rat.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2014
Same author

Neurogenesis of the magnocellular basal telencephalic nuclei in the rat.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2014
Same author

Effects of selective doses of x-irradiation on the levels of several amino acids in the cerebellum of the rat.

Neurochemical research·2013
Same author

Effects of cycloate on development of Heterodera schachtii and growth of three Beta species.

Journal of nematology·2009

Area of Science:

  • Developmental biology
  • Neuroscience
  • Comparative anatomy

Background:

  • The embryonic forebrain undergoes complex transformations during development.
  • Understanding the spatiotemporal dynamics of forebrain growth is crucial for developmental neuroscience.

Purpose of the Study:

  • To investigate the volumetric changes and structural development of the rat embryonic forebrain from embryonic day 12 to 21.
  • To analyze the differential growth patterns of the telencephalon and diencephalon, and their associated ventricles and neuroepithelium.

Main Methods:

  • Computerized three-dimensional reconstruction of serially sectioned rat embryos.
  • Quantitative analysis of forebrain volume, ventricular size, neuroepithelium, and parenchyma volume at specific embryonic days (E12, E15, E18, E21).

Related Experiment Videos

Main Results:

  • The overall embryonic prosencephalon volume increased continuously from E12 to E21.
  • Ventricular and neuroepithelial volumes expanded significantly from E12 to E18, followed by a decrease by E21, while parenchyma volume steadily increased.
  • Telencephalon growth significantly exceeded diencephalon growth between E15 and E21.
  • Lateral ventricle and neuroepithelium volumes in the telencephalon increased from E15 to E18 then decreased by E21; third ventricle and neuroepithelium volumes in the diencephalon continuously declined from E15 to E21.
  • A strong correlation was observed between ventricular and neuroepithelial volume changes, suggesting a 'lock-step' relationship.

Conclusions:

  • Rat forebrain development involves substantial volumetric expansion and structural reorganization, characterized by differential growth of its components.
  • The observed 'lock-step' changes in ventricles and neuroepithelium indicate a tightly regulated developmental process.
  • Findings provide insights into the timing and coordination of forebrain structure development, with implications for understanding neurodevelopmental processes.