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Mouse lemur microscopic MRI brain atlas

P Ghosh1, M O'Dell, P T Narasimhan

  • 1Beckman Institute, Division of Biology, California Institute of Technology, Pasadena 91125, USA.

Neuroimage
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

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We created a high-resolution 3D digital mouse lemur head atlas using magnetic resonance imaging (MRI). This detailed atlas reveals fine anatomical structures, offering a distortion-free alternative to traditional methods for neuroscience research.

Area of Science:

  • Neuroscience
  • Anatomical Imaging
  • Primatology

Background:

  • High-resolution anatomical atlases are crucial for understanding brain structure and function.
  • Traditional histological methods can introduce spatial distortions and registration issues.
  • Microscopic resolution magnetic resonance imaging (MRI) offers a non-invasive alternative.

Purpose of the Study:

  • To develop a detailed 3D digital atlas of a mouse lemur head.
  • To achieve isotropic resolution for accurate anatomical representation.
  • To provide a valuable resource for comparative neuroanatomy and developmental studies.

Main Methods:

  • Acquisition of 3D proton magnetic resonance images (MRI) at 500 MHz.
  • Utilized a spin-echo pulse sequence with optimized T2 and diffusion weighting.

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  • Employed 3D volume-rendering and contiguous 2D plane cuts for visualization.

    • Main Results:

    • Generated a 60-micron isotropic resolution 3D digital atlas of a mouse lemur head.
    • Clearly identified familiar anatomical structures, fine fiber tracts, cortical laminations, inner ear details, and lateral geniculate nuclei layering.
    • Demonstrated strong intrinsic contrast between gray and white matter.

    Conclusions:

    • The developed 3D MRI atlas provides unprecedented detail of mouse lemur head anatomy.
    • This atlas overcomes limitations of histological techniques, offering superior spatial accuracy.
    • It serves as a foundational tool for future in vivo longitudinal studies on primate brain development.