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Inhibition of the reuptake of serotonin by tryptoline
Naunyn-Schmiedeberg'S Archives of Pharmacology
|January 14, 1976
Abstract:
Tryptoline, a metabolite of tryptamine, competitively inhibits serotonin accumulation in nuclei-free homogenate of rat "forebrains". After intraventricular injection the drug elicits an increase of serotonin levels in the same part of the brain whereas the monoamine oxidase activity is not altered.