Abnormal hydroxyproline polypeptides in the urine of patients with chronic uremia

An abnormal peak of hydroxyproline polypeptides has been observed when the polypeptide fraction from the urines of patients with advanced chronic uremia was subjected to gel chromatography. This abnormality was apparently related to the degree of uremia and to the presence of uremic osteodystrophy. The abnormal peak was not observed in patients with high turnover bone disease without renal insufficiency and in patients with nephrotic syndrome and normal glomerular filtration rate.