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Inflammatory cells and MHC class II antigens expression in prostate during time-course experimental autoimmune
A C Donadio1, M Depiante-Depaoli
1Departamento de Bioquímica Clínica, Universidad Nacional de Córdoba, Córdoba, 5000, Argentina.
Clinical Immunology and Immunopathology
|November 5, 1997
Summary
This study details immune cell infiltration and MHC class II expression during experimental autoimmune prostatitis (EAP) in rats. Findings reveal evolving inflammatory patterns and cell types, suggesting MHC class II
Area of Science:
- Immunology
- Urology
- Pathology
Background:
- Experimental autoimmune prostatitis (EAP) is a model for studying prostatitis.
- Understanding the immune response in EAP is crucial for developing treatments.
Purpose of the Study:
- To investigate lymphocytic infiltration and phenotype.
- To analyze MHC class II expression during EAP development in rats.
Main Methods:
- Time-course study of EAP development in rats.
- Quantification of inflammatory foci and mononuclear cells.
- Phenotypic analysis of infiltrating immune cells (CD4, CD8, macrophages, mast cells).
- Assessment of MHC class II (IA and IE) expression on epithelial cells.
Main Results:
- Inflammatory foci and mononuclear cell counts increased significantly from day 14 to day 28 post-immunization.
- Infiltrates were primarily CD4 and CD8 T cells, with fewer macrophages and transient mast cells.
- MHC class II antigens were present on epithelial cells, with IE expression peaking at day 21.
Conclusions:
- The immune response in EAP involves significant T cell infiltration.
- Differential expression of MHC class II antigens, particularly IE, may modulate the immune response during EAP.