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Benzoquinones inhibit the expression of inducible nitric oxide synthase gene
M Niwa1, N Nakamura, K Kitajima
1Faculty of Pharmaceutical Sciences, The University of Tokushima, Japan. mniwa@ph.tokushima-u.ac.jp
Biochemical and Biophysical Research Communications
|November 5, 1997
Abstract:
Benzoquinones inhibited the production of NO induced by LPS and gamma-IFN in C6 glia cells. The mechanistic studies showed that benzoquinones inhibited the expression of iNOS mRNA through inactivation of NF kappa B. Benzoquinones may be a useful candidate for the development of a drug to treat disease due to iNOS gene over-expression.