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Related Experiment Videos

Immunomodulation with linomide: possible novel therapy for multiple sclerosis

O Abramsky1, D Lehmann, D Karussis

  • 1Department of Neurology, Hadassah University Hospital, Hebrew University Hadassah Medical School, Jerusalem, Israel.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|November 1, 1996
PubMed
Summary

Linomide, a quinoline carboxamide, effectively reduced symptoms and new lesions in secondary progressive multiple sclerosis patients. This immunomodulatory drug activates natural killer (NK) and suppressor-inducer cells, crucial for inhibiting autoimmune responses.

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Area of Science:

  • Immunology
  • Neuroscience
  • Pharmacology

Background:

  • Linomide is a synthetic quinoline carboxamide with immunomodulatory properties.
  • Previous studies demonstrated Linomide's inhibitory effects on experimental autoimmune encephalomyelitis (EAE).

Purpose of the Study:

  • To evaluate Linomide's efficacy in patients with secondary progressive multiple sclerosis (SPMS).
  • To assess the impact of Linomide on clinical disability and MRI-detected lesions.

Main Methods:

  • A double-blind, placebo-controlled, short-term pilot study.
  • Oral administration of Linomide.
  • Assessment of clinical disability using the Expanded Disability Status Scale (EDSS).
  • Serial monthly MRI scans to quantify new lesions.

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Main Results:

  • Linomide significantly improved the EDSS score (P = 0.045).
  • A significant reduction in the mean total number of new MRI lesions was observed (P = 0.021).
  • Increased CD45Ra, CD8, and CD16 positive cells suggest activation of suppressor-inducer, suppressor, and NK cells.

Conclusions:

  • Linomide demonstrates a beneficial effect in managing secondary progressive multiple sclerosis.
  • The drug's mechanism may involve the activation of suppressor-inducer, suppressor, and NK cells to inhibit autoimmune responses.