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Mechanism of catalysis by retaining beta-glycosyl hydrolases
1Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02254-9110, USA. awhite@auriga.rose.brandeis.edu
Current Opinion in Structural Biology
|November 5, 1997
Abstract:
Recent structural studies provide a fresh look at the catalytic mechanism of polysaccharide hydrolysis by retaining beta-glycosyl hydrolases. Highlights include insights into saccharide ring distortion, both upon binding and during the course of catalysis, and evidence for the regulation of the pKa of key catalytic residues.