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The benefits of atomic resolution
Z Dauter1, V S Lamzin, K S Wilson
1Department of Chemistry, University of York, Heslington, UK. dauter@yorvic.york.ac.uk
Current Opinion in Structural Biology
|November 5, 1997
Summary
Protein crystal structure determination at atomic resolution is advancing, with technology readily available. Biologically significant results are emerging from these structural studies.
Area of Science:
- Structural Biology
- Biochemistry
- Molecular Biophysics
Background:
- Protein crystallography is a key technique for understanding molecular mechanisms.
- Advances in technology have enabled higher resolution protein structure determination.
- The field is transitioning from demonstration projects to biologically relevant applications.
Purpose of the Study:
- To highlight the maturation of atomic resolution protein crystal structure elucidation.
- To discuss the expanding applications of crystallographic data in structure solution and refinement.
- To underscore the emerging biological significance of protein structural data.
Main Methods:
- Data collection using advanced techniques.
- Computational hardware and software for structure analysis.
- Analysis of protein crystal structures at atomic resolution.
Main Results:
- The field of protein crystallography is maturing, with accessible technology.
- Current literature primarily features demonstration projects on native proteins.
- Early biologically significant results involving ligand complexes and prosthetic groups are emerging.
Conclusions:
- Atomic resolution protein structure determination is a rapidly advancing field.
- The availability of technology facilitates widespread application.
- Emerging results promise significant biological insights.