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Unusual lactam formation occurring in the synthesis of a biotinylated T-antigen-serine derivative
S Bay1, O Berthier-Vergnes, V Biberovic
1Institut Pasteur, Département de Biochimie et Génétique Moléculaire, Paris, France.
Carbohydrate Research
|August 25, 1997
Abstract:
Synthesis of the biotinylated T-antigens, linked to a serine by an alpha (7 alpha) or a beta (7 beta) 2-acetamido-2-deoxy-D-galactoside bond, is described. These derivatives were needed for the detection of a specific endogenous lectin at the surface and/or on the migration pathway of melanoma cells. In the course of the synthesis, an unusual lactam formation was observed with the beta anomer of the azido-disaccharide 5 beta.