Related Experiment Videos
Synthesis of lactosyl phosphate diester derivatives of nucleosides
1National Research Laboratories of Natural and Biomimetic Drugs, Beijing Medical University, China.
Carbohydrate Research
|August 25, 1997
Abstract:
Derivatives of the lactosyl phosphate diester and the lactosyl thiophosphate diester of 1-(beta-D-arabinofuranosyl)cytosine (Ara-C) and 9-(beta-D-arabinofuranosyl)adenine (Ara-A) were synthesized by condensation of 3-hydroxypropyl lactoside and a protected Ara-C or Ara-A via H-phosphonate methodology and phosphoramidite methodology, respectively.