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Related Experiment Videos

Retransplantation for recurrent hepatitis C

P A Sheiner1, L K Schluger, S Emre

  • 1Department of Surgery, Mount Sinai Medical Center of the City University of New York, New York, USA.

Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
|March 1, 1997
PubMed
Summary

Liver retransplantation for recurrent hepatitis C virus (HCV) is a viable option, with 8 of 14 patients surviving long-term. Early retransplantation before complications improves outcomes for patients with progressive liver disease.

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Area of Science:

  • Hepatology
  • Transplant Surgery
  • Virology

Background:

  • Recurrence of hepatitis C virus (HCV) post-liver transplant can lead to graft failure.
  • Outcomes after retransplantation for recurrent HCV are not well-established.

Purpose of the Study:

  • To analyze the outcomes of retransplantation (re-OLT) in patients with recurrent hepatitis C after orthotopic liver transplant (OLT).

Main Methods:

  • Retrospective analysis of 14 patients undergoing re-OLT for recurrent hepatitis C.
  • HCV-RNA testing via PCR performed on 12 patients.
  • Histopathological examination of explanted livers.

Main Results:

  • Eight patients (57%) survived long-term (median 926 days).

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  • Four patients died perioperatively due to sepsis; three had pre-existing renal failure.
  • Complications included cytomegalovirus infection and chronic rejection.
  • Three patients showed mild recurrent hepatitis, one had steatosis, and four had no recurrence at follow-up.

    • Conclusions:

    • Retransplantation for recurrent hepatitis C is a viable option for end-stage liver dysfunction.
    • Performing re-OLT before infectious complications and renal insufficiency is crucial for better outcomes.