NLPR, an agonist of AVP4-8, increases NGF gene expression in memory-impaired rat brain

¹Shanghai Institute of Biochemistry, Academia Sinica, China.

Biomedical Peptides, Proteins & Nucleic Acids : Structure, Synthesis & Biological Activity

|January 1, 1994

Abstract:

Oral administration of the tetrapeptide Asn-Leu-Pro-Arg (NLPR) to memory-impaired rats results in improved acquisition and maintenance of behavioural response and also facilitates nerve growth factor (NGF) expression in the brain. It is suggested that NLPR can ameliorate memory disability by promoting NGF gene expression, so implying that NLPR is a potential drug candidate for curing memory impairment.

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