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Alzheimer's disease: current knowledge, management and research

S Gauthier1, M Panisset, J Nalbantoglu

  • 1Department of Neurology and Neurosurgery, McGill Centre for Studies in Aging, McGill University, Montreal, Que.

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
|November 5, 1997
PubMed
Summary

Alzheimer's disease, a common neurological condition, affects individuals over 85. Early diagnosis and management, including medications like donepezil, can help stabilize symptoms and potentially prevent future progression.

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Area of Science:

  • Neurology
  • Geriatrics
  • Genetics

Background:

  • Alzheimer's disease (AD) is a prevalent neurological disorder.
  • Onset can occur as early as age 40, with incidence rising sharply after age 85.
  • Genetic factors and lifetime events influence AD development.

Purpose of the Study:

  • To outline the diagnostic and management strategies for Alzheimer's disease.
  • To discuss the natural history and progression of the condition.
  • To highlight current and future therapeutic possibilities.

Main Methods:

  • Clinical diagnosis relies on detailed patient history and informant reports.
  • Minimal laboratory testing aids in diagnosis.
  • Observation of the disease's natural progression through distinct stages.

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Main Results:

  • Alzheimer's disease follows a predictable course with stages of cognitive decline, functional impairment, and behavioral changes.
  • Medications such as donepezil can improve or stabilize symptoms.
  • Primary care physicians can manage AD with appropriate expertise.

Conclusions:

  • Early diagnosis and management are crucial for Alzheimer's disease.
  • Current treatments offer symptomatic relief and stabilization.
  • Future research holds promise for disease prevention and more effective therapies.