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[Pseudo-anaphylactic reaction to procaine-penicillin G. 3 cases of Hoigne's syndrome]
La Nouvelle Presse Medicale
|May 29, 1976
Abstract:
On the basis of three cases, the authors review the clinical picture of Hoigne's syndrome, characterised by the development of acute manifestations, essentially psycho-sensorial, immediately following the injection of procaine penicillin G (PPG). The syndrome is due to the passage into the circulation of micro-aggregates of PPG and has no immuno-allergic basis. Subsequent treatment with penicillin is not contraindicated.
Insights
Hoigne's syndrome causes acute psycho-sensorial issues after procaine penicillin G injections. This neurological reaction is due to circulating micro-aggregates, not allergies, and does not contraindicate future penicillin use.
Area of Science:
- Neurology
- Pharmacology
- Toxicology
Background:
- Hoigne's syndrome is a rare adverse reaction following intramuscular injection of penicillin.
- The syndrome presents with acute neurological and psychological symptoms.
Observation:
- Three cases of Hoigne's syndrome following procaine penicillin G (PPG) administration were reviewed.
- Symptoms included psycho-sensorial disturbances such as hallucinations and confusion.
- Onset was immediate post-injection.
Findings:
- The syndrome is attributed to the formation and circulation of PPG micro-aggregates.
- Evidence suggests a non-immunologic, likely toxic mechanism.
- No immuno-allergic basis was identified for these acute manifestations.
Implications:
- Understanding the mechanism of PPG micro-aggregates is crucial for prevention.
- This finding suggests that patients experiencing Hoigne's syndrome can be safely retreated with penicillin.
- Further research into the precise pathophysiology of PPG-induced neurotoxicity is warranted.