A result on a 2 x 2 survival experiment
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Updated: Oct 31, 2026

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy
Published on: January 19, 2019
1Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502, USA.
Abstract:
Lifetime data classified according to categorical variables under the proportionality of the hazard functions of response variables for various treatment combinations is assumed. The proposed model is a combination of Cox's proportional hazards model and ANOVA model. The existence of a solution to the marginal likelihood function is examined for the case of 2 x 2 two-way classification. We provide an easily verifiable condition for the existence of a unique estimate.
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